Diverse types of genetic variation converge on functional gene networks involved in schizophrenia
… identify and analyze disease-related gene networks 11,12,13,… of diverse sources of
genome-wide genetic variation under a … the convergence of different types of genetic variations on …
genome-wide genetic variation under a … the convergence of different types of genetic variations on …
[HTML][HTML] Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
M Ayalew, H Le-Niculescu, DF Levey, N Jain… - Molecular …, 2012 - nature.com
… convergent functional genomics (CFG) approach to identify and prioritize genes involved in
schizophrenia, by gene-… environmental component or having a different genetic component. …
schizophrenia, by gene-… environmental component or having a different genetic component. …
Convergence and divergence in the genetics of psychiatric disorders from pathways to developmental stages
… risk factors for major neuropsychiatric disorders (schizophrenia… functional convergence
most relevant to a specific condition will likely be shared across different types of genetic variants …
most relevant to a specific condition will likely be shared across different types of genetic variants …
Identifying gene regulatory networks in schizophrenia
SG Potkin, F Macciardi, G Guffanti, JH Fallon, Q Wang… - Neuroimage, 2010 - Elsevier
… , induced by genetic variations in the coding or regulatory … inferred from prefrontal cortex
gene expression in 42 different … component of a schizophrenia-related gene network. In support …
gene expression in 42 different … component of a schizophrenia-related gene network. In support …
Towards understanding the schizophrenia code: an expanded convergent functional genomics approach
H Le‐Niculescu, Y Balaraman, S Patel… - … of Medical Genetics …, 2007 - Wiley Online Library
… candidate genes than the genes that still change during co-… surveyed gene expression
changes across six different brain … potentially implicated in the pathophysiology of schizophrenia …
changes across six different brain … potentially implicated in the pathophysiology of schizophrenia …
Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity
J Hall, S Trent, KL Thomas, MC O'Donovan… - Biological psychiatry, 2015 - Elsevier
… across different studies but also their convergence into a … The identification of convergent
biological pathways involved … in schizophrenia provides a framework for future functional …
biological pathways involved … in schizophrenia provides a framework for future functional …
… schizophrenia genes reveal schizophrenia susceptibility genes converge on common molecular networks and enrichment of nucleosome (chromatin) assembly genes …
… schizophrenia susceptibility genes, it is frequently observed that different genetic variants
are identified in different … This functional convergence also indicates that common molecular …
are identified in different … This functional convergence also indicates that common molecular …
[HTML][HTML] Common and rare genetic risk factors converge in protein interaction networks underlying schizophrenia
… Among the different types of gene networks, protein-protein interaction (PPI) networks have
… We hypothesize that a group of functionally related genes with nominal significance could …
… We hypothesize that a group of functionally related genes with nominal significance could …
Convergence and divergence of rare genetic disorders on brain phenotypes: a review
… and effect sizes of genetic variation on autism spectrum … phenotypic convergence and
divergence between different … genes in CNVs associated with ASD and schizophrenia with …
divergence between different … genes in CNVs associated with ASD and schizophrenia with …
… spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants
BJ Mowry, J Gratten - Molecular psychiatry, 2013 - nature.com
… We conclude that diverse approaches will be required to … , epidemiological and genetic,
have converged to challenge … goal of schizophrenia genetics is to identify genetic variants and …
have converged to challenge … goal of schizophrenia genetics is to identify genetic variants and …